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Lecture, conference, laboratory. Synthesis, chemistry of carboxylic acids and derivatives pKa of acids, nucleophilic substitution of derivatives, acyl chlorides, esters, amides, anhydrides, nitriles. Carbohydrates stereochemistry, aldoketoses, aldopentoses, aldohexoses, ketosugars, derivatives, furanose and pyranose forms, reducing and nonreducing sugars, disaccharides and polysaccharides; fats and oils; aromatic hydrocarbons benzene, resonance and molecular orbital approaches, electrophilic and nucleophilic aromatic substitution; aromatic nitrogen and oxygen chemistry diazotization, synthesis; chemistry of amines, amino acids, peptides, proteins, DNA; other topics. Lecture, discussion, laboratory. Prerequisites: CHEM 210. Restrictions: Sophomore standing required. Usually offered: Annually, fall and spring semester. Semester credits: 1 4. Content: Chemical synthesis using the systematic "synthon" approach to design retrosynthetic pathways for complex molecules. Approaches for advanced stereochemical control. Successful synthesis routes in the primary literature examined and the experimental section of these articles interpreted to successfully bridge the gap from journal to bench.



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